Mechanistic aspects of CPP-mediated intracellular drug delivery: Relevance of CPP self-assembly

CPP-Assisted Intracellular Drug Delivery, What Is Next?

For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, thereby denying their clinical potential to become potent anti-cancer drugs. B...

Building Cell Selectivity into CPP-Mediated Strategies

There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, th...

Efficient Intracellular Delivery of Nucleic Acids using Cell-Penetrating Peptides (CPP)

Vol. XXX, No. XX ’ XXXX ’ 000–000 ’ ACCOUNTS OF CHEMICAL RESEARCH ’ A 10.1021/ar200256e & XXXX American Chemical Society Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides IKUHIKO NAKASE, HIDETAKA AKITA, KENTARO KOGURE, ASTRID GRÄSLUND, ) € ULO LANGEL, HIDEYOSHI HARASHIMA, AND SHIROH FUTAKI* † Institute for Chemical Research, Kyoto University, Uji, ...

P 017 Intracellular fate of CPP disulfide - linked PN�s

Characterization of Pth-cpp Fusion Peptides for Oral Delivery